Double-blind trial of deglycyrrhizinated liquorice in gastric ulcer

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Double-blind trial of deglycyrrhizinated liquorice in gastric ulcer.

In order to investigate further the reported beneficial effect of deglycyrrhizinated liquorice in gastric ulcer, a trial with a double-blind, cross-over design was performed. The patients were treated during two consecutive periods of four weeks each with either liquorice extract during the first period and placebo during the second or placebo during the first period and liquorice during the se...

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Clinical trial of deglycyrrhizinized liquorice in gastric ulcer.

In the past twenty years evidence has accumulated that liquorice and related compounds accelerate the rate of healing of gastric ulcers. Powdered succus liquiritiae (Revers, 1948) and glycyrrhiza extract (Schulze, Franke, and Keller, 1954; Ferenbach, 1954; Ohrt, 1955) were shown to be beneficial in patients with gastric ulcer but adequately controlled clinical trials of liquorice extracts were ...

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Clinical trial of deglycyrrhizinised liquorice in gastric ulcer.

Ninety-six patients with gastric ulcer were randomly allocated to treatment either with deglycyrrhizinised liquorice or placebo. After four weeks no differences were found between the treatment groups in the proportions with complete healing, whether assessed by gastroscopy or radiology, or in the percentage reduction in ulcer area, or in clinical improvement.

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Double-blind controlled trial of cimetidine in the healing of gastric ulcer.

Sixty patients with gastric ulcers were treated for four weeks with either 1 g cimetidine per day or with identical tablets containing lactose. The healing rate, assessed by endoscopy, was 23 out of 35 (66%) in the patients given cimetidine and 13 out of 25 (52%) in those given placebo. The difference between the groups is not significant. During each of the four weeks of the study the cimetidi...

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Excretion studies of nitrofurantoin and nitrofurantoin with deglycyrrhizinated liquorice.

Nitrofurantoin and nitrofurantoin with liquorice were given to healthy volunteers and patients suffering from urinary tract infections. The excretion rates of the drug, colony counts and side effects were studied in patients and excretion rates in the volunteers. The excretion rates of the drug were significantly higher in patients receiving the drug with liquorice and also side effects were mi...

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ژورنال

عنوان ژورنال: Gut

سال: 1973

ISSN: 0017-5749

DOI: 10.1136/gut.14.9.711